Central Dogma

Hi Everyone, 

        What is the term Central Dogma? The process of conversion of DNA into RNA and then into functional protein is known as central dogma. In simple terms, the flow of information in the DNA into a functional protein. This term was introduced by Francis Crick in 1958. This involves,

1. Replication - Making new DNA from the existing one.

2. Transcription - Conversion of DNA to RNA.

3. Translation - Conversation of RNA to proteins. 

    Our DNA carries all information needed to produce the required proteins. During transcription, the information in the DNA is converted to small RNA messages. These messages are converted to specific proteins in ribosomes during translation. The process of transcription and translation together is called gene expression.

Note:

    Although central dogma explains how genetic information flows, there are some deviations in this concept. An example is non-coding RNA (ncRNA). This transcribed RNA doesn't convert into proteins. The role of ncRNA is being studied. 

Let us study more about non-coding RNA in our next blog.

Thank you!

Reference:

• What is the ‘Central Dogma’? (n.d.). @Yourgenome · Science Website. https://www.yourgenome.org/facts/what-is-the-central-dogma/